Medpage Today, Mar. 28, 2012
Cases of childhood narcolepsy spiked in Finland in 2010, and researchers there are suggesting the adjuvanted vaccine against the H1N1 pandemic flu might have been a trigger.
Two related studies, appearing online in PLoS ONE found that the incidence of narcolepsy rose markedly in children and adolescents, while remaining unchanged in those 20 and older.
Most of the cases in children occurred after vaccination with the ASO3-adjuvanted flu vaccine Pandemrix, which was the only vaccine used in Finland during the pandemic.
The 50 children with the risk allele all had excessive daytime sleepiness with multiple abnormal sleep latency tests. Their symptoms started abruptly and 47 had cataplexy, which started at the same time or soon after the onset of excessive daytime sleepiness.